General Cell Lines and Cell Cultures
Genscript Corporation CHO-K1/D2/G15 Stable Cell Lin
Dopamine is the predominant catecholamine neurotransmitter found in mammalian brain where it controls a variety of functions including locomotor activity cognition emotion positive reinforcement food intake and endocrine regulation It also plays multiple roles in the periphery as a modulator of cardiovascular function catecholamine release hormone secretion vascular tone renal function and gastrointestinal motility The dopamine receptor family consists of five members which are classified into two groups D1-like (D1 and D5) and D2-like (D2 D3 and D4) Dopamine receptor 2 is mainly expressed in the brain It has splicing variants D2L and D2S D2R receptor is implicated in a number of neurological and psychiatric conditions Drugs acting at dopamine D2 receptors (D2R) are commonly used to alleviate symptoms for Parkinson s disease schizophrenia and depression
Genscript Corporation CHO-K1/B2/G15 Stable Cell Lin
Bradykinin (BK) is a pro-inflammatory polypeptide that can cause pain inflammation increased vascular permeability vasodilation contraction of various smooth muscles and cell proliferation by stimulating B1and B2 receptors B2 receptors are most commonly distributed in the vascular and non-vascular smooth muscle and in the heart The B2 receptor mediates the action of bradykinin (BK) and lysyl-bradykinin (Lys-BK) The stimulation of BK B2 receptors is not only implicated in the pathogenesis of inflammation pain and tissue injury but also in cardioprotective mechanisms So B2 receptor agonists may have important clinical value in the treatment and prevention of various cardiovascular disorders such as hypertension ischaemic heart disease left ventricular hypertrophy ventricular remodeling congestive heart failure and diabetic disorders
Genscript Corporation CHO-K1/KiSS1 Stable Cell Line
Recombinant CHO-K1 cells stably overexpress human KiSS1 receptor (KiSS1R) on the surface and contain high levels of G protein G q to couple with the receptor in downstream signaling pathways
Genscript Corporation CHO-K1/MC5/G15 Stable Cell Li
The melanocortin receptor 5 MC5 receptor is Gs-coupled GPCRs expressed in the adrenal gland fat cells kidney leukocytes lung lymph node mammary gland ovary pituitary testis and uterus Mice with targeted deletion of the MC5 receptor have a defect in water and thermoregulation secondary to their decreased production of sebaceous lipids
Genscript Corporation CHO-K1/EP2/G15 Stable Cell Li
Prostaglandin (PG) E2 exerts its actions by acting on a group of G-protein-coupled receptors (GPCRs) There are four GPCRs responding to PGE2 designated subtypes EP1 EP2 EP3 and EP4 and multiple splicing isoforms of the subtype EP3 The EP subtypes exhibit differences in signal transduction tissue localization and expression regulation Studies have identified that EP2 mediates many processes such as facilitating ovulation and fertilization suppressing dendritic cell differentiation and promoting amyloid- formation in Alzheimer s disease
Genscript Corporation CHO-K1/MC4/G15 cAMP Stable
Human Recombinant CHO-K1/MC4/G 15 (cAMP) Stable Cell Line stably overexpress the melanocortin 4 receptor gene (MC4) This stable cell line product is designed for measuring the In Vitro function of MC4
Genscript Corporation HEK293/ACE2 Stable Cell Line
Recombinant HEK293 cells stably express Angiotensin-converting enzyme 2 (ACE2) on the cell surface The surface expression of ACE2 is validated by FACS analysis This stable cell line product is designed for cell-based binding assays that measure the binding affinity and stability of antibody based biologics binding with ACE2 and can be utilized for SARS-Cov-2 pseudovirus neutralization assay for screening neutralizing antibodies
Genscript Corporation CHO-K1/cyno PD-L1 Stable Cell
Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene The formation of PD-1 receptor / PD-L1 or B7 1 receptor /PD-L1 ligand complex transmits an inhibitory signal which reduces the proliferation of these CD8 T cells at the lymph nodes Supplementary to that PD-1 is also able to control the accumulation of foreign antigen specific T cells in the lymph nodes through apoptosis which is further mediated by a lower regulation of the gene Bcl-2
Genscript Corporation CHO-K1/cyno 4-1BB Stable Cell
4-1BB is a member of the tumor necrosis factor (TNF) receptor family Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9) CD137 and induced by lymphocyte activation (ILA) It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule 4-1BB can be expressed by activated T cells but to a larger extent on CD8 than on CD4 T cells In addition 4-1BB expression is found on dendritic cells follicular dendritic cells natural killer cells granulocytes and cells of blood vessel walls at sites of inflammation
Genscript Corporation CHO-K1/NPY2/Gqi5 Stable Cell L
The NPY family consists of three 36-amino acid peptides neuropeptide Y (NPY) peptide YY (PYY) and pancreatic polypeptide (PP) which bind to the NPY receptors At present five distinct NPY receptors Y1 Y2 Y4 Y5 and y6 have been established by receptor cloning studies and all of them are G sub i /sub -coupled GPCRs Activation of NPY receptors mediate a variety physiological effects including stimulation of food intake inhibition of anxiety in the CNS presynaptic inhibition of neurotransmitter release in the CNS and periphery modulation of circadian rhythm release of pituitary hormones modulation of hippocampal activity pain transmission vasoconstriction inhibition of insulin release and modulation of renal function With regard to endogenous agonists the receptors Y2 preferentially bind NPY and PYY
Genscript Corporation CHO-K1/CD112 Stable Cell Line
Cluster of Differentiation 112 (CD112) also known as poliovirus receptor related protein 2 (PVRL2 or PRR2) is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus and thus is involved in cell to cell spreading of these viruses CD112 protein has been identified as the ligand for DNAM-1 (CD226) and the interaction of CD226/CD112 protein can induce NK cell- and CD8 T cell-mediated cytotoxicity and cytokine secretion CD112 has been regarded as a critical component in allergic reactions and accordingly may function as a novel target for anti-allergic therapy
Genscript Corporation CHO-K1/CD80 Stable Cell Line
Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival It is the ligand for two different proteins on the T cell surface CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) CD80 works in tandem with CD86 to prime T cells
Creative Bioarray MONO-MAC-1 cell line, Catalog No. CSC-C0353, Human, Acute monocytic leukemia (AML FAB M5), Suspension culture, Doubling time 40 hours, 1 x 10^6 cells/ml.
The MONO-MAC-1 cell line is a human cell line sourced from the peripheral blood of a 64-year-old male diagnosed with acute monocytic leukemia (AML FAB M5). Known for its role in HIV-1 research and hematological studies, this less differentiated cell line supports productive HIV-1 infection, making it a critical model for examining monocytic functions and disease mechanisms.
- Catalog number: CSC-C0353
- Species: Human
- Source: Peripheral blood from a patient with acute monocytic leukemia
- Morphology: Single, round/multiformed cells in suspension
- Doubling time: 30-50 hours
- Mycoplasma status: Negative
- Biosafety level: 1
- Supports productive infection with HIV-1
- Storage conditions: Frozen with medium and DMSO
Discovery Life Sciences CELLS HU OATP1BE 10E7
Corning TransportoCells Organic Anion-transporting Polypeptide, 10 Million Cells